Publication: Structural comparison of LPG of two Leishmania species

Researchers have provided the first evidence that two Leishmania species possess similar, highly modified lipophosphoglycan (LPG), which enables them to develop in the same sand fly vector.

Writing in Parasitology International, they report: “The lipophosphoglycan (LPG) of Leishmania major has a major role in the attachment to Phlebotomus papatasi midgut. Here, we investigated the comparative structural features of LPG of L. turanica, another species transmitted by P. papatasi.

“The mAb WIC 79.3, specific for terminal Gal(β1,3) side-chains, strongly reacted with L. turanica LPG. In contrast, L. turanica LPG was not recognized by arabinose-specific mAb 3F12. In conclusion, LPGs from L. major and L. turanica are similar, with the latter being less arabinosylated than L. major's. The high galactose content in L. turanica LPG is consistent with its predicted recognition by P. papatasi lectin PpGalec.”

Taken from: Petr Volf, Paula M. Nogueira, Jitka Myskova, Salvatore J. Turco, Rodrigo P. Soares. Structural comparison of lipophosphoglycan from Leishmania turanica and L. major, two species transmitted by Phlebotomus papatasi. Parasitology International, Volume 63, Issue 5, October 2014. Doi: 10.1016/j.parint.2014.05.004 (EDENext232)

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Published: 07/05/2015

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