Publication: Hantavirus infections investigated in Turkey

Researchers believe hantavirus infection should be taken into consideration in patients with clinically suspected Crimean Congo haemorrhagic fever virus and have established that hantavirus was circulating in the Western Black Sea region of Turkey before the 2009 outbreak.

Writing in Acta Medica Mediterranea, they report: “The Hantaviruses and Crimean Congo haemorrhagic fever virus (CCHFV) are members of the Bunyaviridae family. Hantavirus infections causes two main febrile diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses are transmitted by rodents. In 2009, a hantavirus outbreak occurred in the Western Black Sea region of Turkey. For the last 10 years, the prevalence of CCHFV has also been high in this region.

“We screened patients’ samples for the presence of hantavirus IgM and IgG using ELISA on 42 clinically suspect CCHF cases which were CCHFV real-time-RT-PCR and anti-CCHFV IgM negative without a tick-bite history. The current study was carried out on samples sent between March and September of 2008. SELISA-seropositivity was further evaluated using immunofluorescence assay, immunblotting, and FRNT (focus reduction neutralization test). Real-time-PCR was performed to genotype the seropositive cases.

“Anti-Hantavirus IgM and IgG positivity were detected in 3 samples (7.1%) by ELISA and immunoblotting tests. Two had a 1:640 titer against Puumala virus (PUUV) strain by FRNT, while all three samples were found negative for Dobrova virus (DOBV). Thus, hantavirus-specific antibodies could be confirmed detected in 2 out of 42 sera (4.8%) by FRNT.

“The authors postulate that Hantavirus infection should be taken into consideration in patients with clinically suspected CCHFV infection. This study also shows that Hantavirus was circulating in the area before the 2009 hantavirus outbreak in the Western Black Sea region of Turkey.”

Taken from: Yavuz Uyar, Dilek Yagci Caglayik, Gülay Korukluoglu, Ahmet Carhan, Mustafa Ertek, Christel Cochez, Jenny Verner-Carlsson, Ake Lundkvist and Paul Heyman. Investigation of hantavirus infections among CCHFV negative cases in the Western Black Sea region of Turkey. Acta Medica Mediterranea, 2014, 30: 855 (EDENext105)

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Published: 05/05/2015

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